Synthesis and carbonic anhydrase I, II, IX and XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties

R = Ph, benzyl, substituted aryl; etc. KI (hCA I) = 9.4-896.8 nM; KI (hCA II) = 1.0-1427 nM; KI (hCA IX) = 0.91-120.7 nM; KI (hCA XII) = 1.0-84.5 nM.