Synthesis and biological validation of N7-(4-chlorophenoxyethyl) substituted dinucleotide cap analogs for mRNA translation

Design, synthesis and substrate properties of N7-(4-chlorophenoxyethyl) substituted cap analog, that is, N7-(4-chlorophenoxyethyl)-G(5′)ppp(5′)G (5a) and N7-(4-chlorophenoxyethyl)-m3′-OG(5′)ppp(5′)G (5b) are reported.