An insight into synthetic Schiff bases revealing antiproliferative activities in vitro

Abilities of a large number of diversified synthetic Schiff bases of aldimine- and ketimine-types to inhibit the in vitro proliferation rate of human cancer cell lines are reviewed and discussed taking into account the substitution pattern within the sets of different templates studied. A number of them have revealed promising antiproliferative activities against various human tumour cells. The existing structure libraries of these compounds might be undoubtedly of particular interest for further fruitful modification in the rational design of novel antitumour active azomethine lead structures being promising for further development.