Solubilization of haloperidol by acyclic succinoglycan oligosaccharides

► Succinoglycan oligosaccharides functioned as a novel solubilizer on haloperidol. ► Acyclic oligosaccharides increased the solubility of haloperidol up to 87 fold. ► Acyclic succinoglycan acted as a better solubilizer than cyclodextrins. ► Hypothetical model was suggested by computational and NMR spectroscopic analysis.