Nano-inside-micro: Disease-responsive microgels with encapsulated nanoparticles for intracellular drug delivery to the deep lung

Enzyme-responsive PEG-peptide microgels for pulmonary delivery are formed by a facile Michael addition during emulsion (MADE) cross-linking, carry nanoparticles and biologics, exhibit rapid enzyme-triggered release, and avoid long-term clearance by macrophages.356