کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10730548 | 1042598 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Simple automated preparation of O-[11C]methyl-l-tyrosine for routine clinical use
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The previously reported preparation of O-[11C]methyl-l-tyrosine ([11C]MT), a promising tumor imaging agent, has been now considerably simplified and automated. Main changes were the use of [11C]methyl iodide ([11C]MeI) in the reaction with l-tyrosine disodium and the use of solid phase extraction on commercially available cartridges instead of HPLC for the final purification. An injectable saline solution of [11C]MT was obtained within 30Â min after EOB with radiochemical yield of ca. 60% (decay-corrected, based on [11C]MeI). Radiochemical purity was over 97%. The automated preparation was carried out using a miniature module employing manifold valves.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 63, Issue 1, July 2005, Pages 55-61
Journal: Applied Radiation and Isotopes - Volume 63, Issue 1, July 2005, Pages 55-61
نویسندگان
Yoichi Ishikawa, Ren Iwata, Shozo Furumoto, Claudio Pascali, Anna Bogni, Kazuo Kubota, Kiichi Ishiwata,