کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10752468 | 1050327 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of retinoid X receptor gamma expression by fed state in mouse liver
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کلمات کلیدی
EMSALXREG6PaseChREBPRXRRARL-PKLXRFXRSREBP-1cRetinoid X receptorPEPCKLXR response elementBATPPARγPGC-1aRT-PCRGAPDHfarnesoid X receptor - Farnesoid X گیرندهElectrophoretic mobility shift assay - آزمون تحرک تحرک الکتروفورزWhite adipose tissue - بافت چربی سفیدbrown adipose tissue - بافت چربی قهوه ایFeeding - تغذیهphosphoenolpyruvate carboxykinase - فسفوآنولپیرود کربوکسیکینازLipid metabolism - متابولیسم لیپیدreverse transcription-polymerase chain reaction - واکنش زنجیره ای رونویسی-پلیمراز معکوسWAT - چیLiver - کبدliver X receptor - کبد X گیرندهPeroxisome proliferator-activated receptor gamma - گاما گیرنده گیرنده فعال پرولیفیزوم فعالGlucose - گلوکزglucose-6-phosphatase - گلوکز 6-فسفاتازglyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژنازRetinoic acid receptor - گیرنده اسید رتینوئیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Glucose metabolism is balanced by glycolysis and gluconeogenesis with precise control in the liver. The expression of genes related to glucose metabolism is regulated primarily by glucose and insulin at transcriptional level. Nuclear receptors play important roles in regulating the gene expression of glucose metabolism at transcriptional level. Some of these nuclear receptors form heterodimers with RXRs to bind to their specific regulatory elements on the target promoters. To date, three isotypes of RXRs have been identified; RXRα, RXRβ and RXRγ. However, their involvement in the interactions with other nuclear receptors in the liver remains unclear. In this study, we found RXRγ is rapidly induced after feeding in the mouse liver, indicating a potential role of RXRγ in controlling glucose or lipid metabolism in the fasting-feeding cycle. In addition, RXRγ expression was upregulated by glucose in primary hepatocytes. This implies that glucose metabolism governed by RXRγ in conjunction with other nuclear receptors. The luciferase reporter assay showed that RXRγ as well as RXRα increased SREBP-1c promoter activity in hepatocytes. These results suggest that RXRγ may play an important role in tight control of glucose metabolism in the fasting-feeding cycle.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 458, Issue 1, 27 February 2015, Pages 134-139
Journal: Biochemical and Biophysical Research Communications - Volume 458, Issue 1, 27 February 2015, Pages 134-139
نویسندگان
Sangkyu Park, Yoo Jeong Lee, Eun Hee Ko, Jae-woo Kim,