EpCAM expression in the prostate cancer makes the difference in the response to growth factors

- EpCAM is heterogeneously expressed in prostate cancer both in vitro and in vivo.
- mTOR signaling is differentially regulated in EpCAM-high and -low subpopulations.
- EpCAM induces the susceptibility to EGF ligand and sustained EGFR activation.
- There is a positive correlation between EpCAM and LAT1 expression.
- EpCAM works as a sensor for the available growth factors to activate AMPK signal.