Hepatoma-derived growth factor stimulates podosome rosettes formation in NIH/3T3 cells through the activation of phosphatidylinositol 3-kinase/Akt pathway

► HDGF stimulates podosome formation, dorsal ruffles formation and cell migration. ► PI3K/Akt signaling cascade is involved in the HDGF-mediated cell migration. ► Ad-PTENT inhibits HDGF-mediated cell migration and PI3K/Akt signaling. ► LY294002 suppresses HDGF-mediated cytoskeleton reorganization and migration.