Regulation of the glutamate transporter EAAT3 by mammalian target of rapamycin mTOR

► Mammalian target of rapamycin (mTOR) up-regulates excitatory amino acid transporter EAAT3. ► The effect is reversed by rapamycin. ► mTOR coexpression increases EAAT3 protein abundance in the cell membrane. ► mTOR presumably increases carrier protein insertion into the cell membrane. ► The effect of mTOR may impact of neuroexcitotoxicity and regulation of autophagy.