Protease-activated receptor-2 (PAR2) mediates VEGF production through the ERK1/2 pathway in human glioblastoma cell lines

► PAR1 or PAR2 in GBM cells elicits signaling pathways involving ERK 1/2 and Akt. ► PAR2 but not PAR1 activation induces VEGF production by human GBM cell lines. ► VEGF production induced by PAR2 activation is mediated by MAPK kinase pathways.