Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells

► The cytotoxicity of juglone is markedly increased by ascorbate. ► T24 cell death by oxidative stress is necrosis-like. ► Redox cycling by juglone/ascorbate inhibits cell proliferation. ► Cellular migration is impaired by juglone/ascorbate.