Nuclear IL-33 is a transcriptional regulator of NF-κB p65 and induces endothelial cell activation

► IL-33 as nuclear factor regulated expression of ICAM-1 and VCAM-1. ► Nuclear IL-33 increased the transcription of NF-κB p65 by binding to the p65 promoter. ► Nuclear IL-33 controls NF-κB-dependent inflammatory responses.