Functional characterization of lipase in the pathogenesis of Staphylococcus aureus

► Lipase mutant was constructed and its roles in pathogenesis were characterized. ► Lipase mutant displays defect in peritoneal abscess formation in Staphylococcus aureus. ► Lipase mutant decreases biofilm formation in S. aureus. ► Lipase protects mice against lethal challenge of S. aureus.