XPD could suppress growth of HepG2.2.15 and down-regulate the expression of hepatitis B virus x protein through P53 pathway

► XPD up-regulated the expressions of P53, phospho-P53(ser-15), P21. ► XPD down-regulated the expressions of Bcl-2 and HBx. ► XPD inhibited the viability of HepG2.2.15 and exacerbated the apoptosis. ► Pifithrin-α, Inhibitor of P53, abolished above-mentioned effects of XPD.