Mediation of glucolipotoxicity in INS-1 rat insulinoma cells by small heterodimer partner interacting leucine zipper protein (SMILE)

► Glucolipotoxicity is an important factor in beta cell dysfunction. ► High glucose and palmitate induces SMILE expression in INS-1 cells. ► Overexpression of SMILE decreases insulin gene expression and insulin secretion. ► Beta cell dysfunction induced by high glucose and palmitate is mediated by SMILE.