Proprotein convertases in post-menopausal endometrial cancer: Distinctive regulation and non-invasive diagnosis

► Furin is increased in the endometrium with increasing grades of endometrial cancer. ► PC5/6, PACE4 and PC7 are decreased in the endometrium with increasing cancer grades. ► PC activity in uterine lavage is significantly elevated with endometrial cancer. ► Measuring PC activity in uterine lavage may help to detect endometrial cancer.