Foenumoside B from Lysimachia foenum-graecum inhibits adipocyte differentiation and obesity induced by high-fat diet

► Foenumoside B was isolated from Lysimachia foenum-graecum. ► Foenumoside B inhibited adipogenesis and shifted lipid metabolism toward lipolysis. ► Foenumoside B activated AMPK. ► Foenumoside B improved high-fat diet-induced obesity in mouse. ► Foenumoside B has a therapeutic potential for anti-obesity medication.