ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion

► The identification of ARHGAP30, a novel RhoGAP. ► ARHGAP30 and the related protein CdGAP bind the Rho GTPase member Wrch-1. ► ARHGAP30 is a RhoGAP specific for RhoA and Rac1. ► ARHGAP30 is involved in regulation of cell adhesion and actin reorganization.