Soluble factors from IL-1β-stimulated astrocytes activate NR1a/NR2B receptors: Implications for HIV-1-induced neurodegeneration

► IL-1β-stimulated astrocytes produce soluble factors. ► Astrocyte-released soluble factors activate NR2B-containing NMDA receptors. ► Astrocyte-induced NMDA receptor activation has implications for neurodegeneration.