A 43Â kD protein from the leaves of the herb Cajanus indicus L. modulates doxorubicin induced nephrotoxicity via MAPKs and both mitochondria dependent and independent pathways

► Nephroprotective role of CI protein in Dox-induced renal damage was investigated. ► Doxorubicine activates both intrinsic and extrinsic apoptotic pathways. ► Doxorubicine activates the MAPKs family proteins. ► CI protein reduced oxidative stress, renal dysfunction and apoptotic cell death. ► CI protein might act as a beneficial agent in Dox-induced renal dysfunctions.