کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1082469 950944 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diagnostic interval and mortality in colorectal cancer: U-shaped association demonstrated for three different datasets
ترجمه فارسی عنوان
فاصله تشخیصی و مرگ و میر در سرطان کولورکتال: ارتباط U شکل نشان داده شده برای سه مجموعه داده های مختلف
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
چکیده انگلیسی

ObjectiveTo test the theory of a U-shaped association between time from the first presentation of symptoms in primary care to the diagnosis (the diagnostic interval) and mortality after diagnosis of colorectal cancer (CRC).Study Design and SettingThree population-based studies in Denmark and the United Kingdom using data from general practitioner’s questionnaires, interviewer-administered patient questionnaires, and primary care records, respectively.ResultsDespite variations in the potential selection and information bias when using different methods of identifying the date of first presentation, the association between the length of the diagnostic interval and 5-year mortality rate after the diagnosis of CRC was the same for all three types of data: displaying a U-shaped association with decreasing and subsequently increasing mortality with longer diagnostic intervals.ConclusionUnknown confounding and in particular confounding by indication is likely to explain the counterintuitive findings of higher mortality among patients with very short diagnostic intervals, but cannot explain the increasing mortality with longer diagnostic intervals. The results support the theory that longer diagnostic intervals cause higher mortality in patients with CRC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Epidemiology - Volume 65, Issue 6, June 2012, Pages 669–678
نویسندگان
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