Systematic analysis of genomic organization and structure of long non-coding RNAs in the human genome

► lncRNAs have a lower propensity to cluster compared with other four types of RNA. ► lncRNAs have a higher incidence rate in fragile regions. ► A large number of lncRNAs are associated with different types of repetitive elements. ► Genomic segmental duplication events also promote the expansion of lncRNA family.