کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5305 366 2016 9 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Bioabsorbable radiopaque water-responsive shape memory embolization plug for temporary vascular occlusion
ترجمه فارسی عنوان
بیوجذب رادیواپاک زمان آب حافظه شکل دوشاخه آمبولیزاسیون برای انسداد عروق موقت
کلمات کلیدی
قابل تجزیه زیستی؛ شکل حافظه؛ آمبولیزاسیون؛ پلی (لاکتید-همکاری glycolide)؛ هیدروژل PEG
Biodegradable; Shape-memory; Embolization; Poly(lactide-co- glycolide); PEG hydrogel
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی

We describe the preparation, characterization and evaluation of a biodegradable radiopaque water-triggered shape memory embolization plug for temporary vascular occlusion. The shape memory occluding device consists of a composite of a radio-opaque filler and a poly (dl-lactide-co-glycolide) (PLGA) blend, which was coated with a crosslinked poly (ethylene glycol) diacrylate (PEGDA) hydrogel. The mechanical properties, the degradation timeframe, the effect of programming conditions on the shape memory behaviour and the extent of radio-opacity for imaging were evaluated. Based on the tests, the mechanism responsible for the water-induced shape memory effect in such an embolization plug was elucidated. Suitable materials were optimized to fabricate an embolic plug prototype and its in vitro performance was evaluated as an occlusion rate (using a custom-built set up) and its biocompatibility. Finally, a feasibility study was conducted in vivo in a rabbit model to investigate the ease of device deployment, device migration and extent of vessel occlusion. The in vivo results demonstrated that the prototypes were visible under fluoroscopy and complete vascular occlusion occurred within 2 min of deployment of the prototypes in vivo. In conclusion, the developed embolization plug enables controlled and temporary vascular embolization, and is ready for safety studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 102, September 2016, Pages 98–106
نویسندگان
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