MiR-136 promotes apoptosis of glioma cells by targeting AEG-1 and Bcl-2

► MiR-136 is downregulated in human glioma cell lines and tissues. ► Ectopic expression of miR-136 is able to sensitize glioma cells to cisplatin-induced apoptosis. ► AEG-1 and BCL-2 are two directly targets of miR-136. ► Expression of ectopic AEG-1 or Bcl-2 partially abrogates the effect of miR-136.