Physical and functional interaction of KV10.1 with Rabaptin-5 impacts ion channel trafficking

► Rabaptin-5 interacts with the C-terminus of KV10.1 potassium channels. ► The interaction occurs at then endosomal membrane. ► Silencing of Rabaptin-5 alters channel trafficking to the plasma membrane and recycling. ► KV10.1 co-localizes, but does not physically interact, with Rab7 and Rab11.