Coilin levels modulate cell cycle progression and γH2AX levels in etoposide treated U2OS cells

► Investigated the role of coilin in the DNA damage response. ► Depletion of coilin increased levels of γH2AX in etoposide treated cells. ► Proliferation rate of etoposide treated U2OS cells was influenced by coilin. ► Coilin overexpression in treated cells increases percent of cells in S and G2/M. ► Transfected coilin inhibits the localization of endogenous coilin in treated cells.