Fetuin-A triggers the secretion of a novel set of exosomes in detached tumor cells that mediate their adhesion and spreading

► Fetuin-A mediates the secretion of a novel set of exosomes that we named FetA Exo. ► FetA Exo mediate the adhesion and spreading of cells. ► FetA Exo are loaded with fetuin-A, plasminogen and histones. ► Plasminogen plays a key role in FetA Exo mediated adhesion.