Epigenetic regulation of microRNA-375 and its role in melanoma development in humans

► miR-375 is epigenetically regulated in human melanomas by hypermethylation. ► miR-375 methylation was observed in patient samples derived from primary, regional, distant, and nodular melanomas. ► miR-375 ectopic expression inhibited cell growth, invasion, and induced changes in cell morphology in melanoma cells. ► Gene expression changes suggest possible roles of miR-375 in cytoskeletal architecture, cell motility and migration.