کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10871855 | 1074088 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
RNAIII activates map expression by forming an RNA-RNA complex in Staphylococcus aureus
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Staphylococcus aureus is a gram-positive pathogen responsible for a wide variety of diseases. RNAIII is the key effector of the accessory gene regulator (agr) system. It is a regulatory RNA (514 nucleotides long) that acts at both transcription and translation level to regulate the production of numerous toxins, enzymes and cell surface proteins. Here, we reveal that map (major histocompatibility complex class II analogous protein) is positively regulated by RNAIII. Our further study indicates that the 108-135Â nt fragment of RNAIII acts as an antisense RNA and anneals to map mRNA, forming RNA duplexes. The interaction between RNAIII and map mRNA may activate translation initiation. This may be helpful for understanding the regulation of virulence in S. aureus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 585, Issue 6, 23 March 2011, Pages 899-905
Journal: FEBS Letters - Volume 585, Issue 6, 23 March 2011, Pages 899-905
نویسندگان
Yu Liu, Chunhua Mu, Xiaomin Ying, Wuju Li, Na Wu, Jie Dong, Yaping Gao, Ningsheng Shao, Ming Fan, Guang Yang,