Potamotrygon cf. henlei stingray mucus: Biochemical features of a novel antimicrobial protein

► Potamotrygon cf. henlei venom and mucus are an extensive source of bioactive compounds. ► This study described the biological properties of a antimicrobial protein from mucus. ► The protein named PcfHb has 16072.8 Da and is similar to the β-chain of hemoglobin. ► PcfHb was active against bacteria, yeast and assayed for its role on the microcirculation. ► This is the first description of a bioactive polypeptide from the mucus of a stingray.