کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10902380 | 1084763 | 2014 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MicroRNAs as regulatory elements in triple negative breast cancer
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کلمات کلیدی
NF-κBTNBCHER2VHLPKCαXIAPVon Hippel–Lindau - از Hippel-LindauRISC - خطرretinoblastoma - رتینوبلاستوما، تومور شبکیهTriple negative breast cancer - سرطان سینه سه گانه منفیnuclear factor κB - فاکتور هسته ای κBRNA-Induced Silencing Complex - مجتمع خاموش کننده RNA inducedX-linked inhibitor of apoptosis - مهارکننده آپوپتوز X مرتبط با آنProtein kinase Cα - پروتئین کیناز CαHuman epidermal growth factor receptor 2 - گیرنده عامل فاکتور رشد اپیدرمی انسان 2
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Triple negative breast cancer is a very aggressive subtype of breast cancer characterized by high recurrence rates and a greater likelihood of death compared to other breast cancers. Additionally, it is characterized by lack of expression of the estrogen and progesterone receptors and human epidermal growth factor receptor 2 (HER2)/neu. The current treatment for triple negative breast cancer is chemotherapy and that often results in a poor outcome. Therefore, it is essential that new, alternative therapeutic targets are identified. MicroRNAs are small non-coding elements that regulate the expression of various genes. Research has identified microRNAs promoting and in some cases suppressing cell proliferation by targeting genes in triple negative breast cancer cells. Thus, they are promising cancer targets and they should be further investigated as they could function as biomarkers of triple negative breast cancer in the future. Here we focus on the role of microRNAs in triple negative breast cancer and their potential as therapeutic targets.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 354, Issue 1, 1 November 2014, Pages 1-4
Journal: Cancer Letters - Volume 354, Issue 1, 1 November 2014, Pages 1-4
نویسندگان
Melina-Theoni Gyparaki, Efthimia K. Basdra, Athanasios G. Papavassiliou,