کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10914877 | 1088822 | 2014 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The tumor promoting activity of the EP4 receptor for prostaglandin E2 in murine skin
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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![عکس صفحه اول مقاله: The tumor promoting activity of the EP4 receptor for prostaglandin E2 in murine skin The tumor promoting activity of the EP4 receptor for prostaglandin E2 in murine skin](/preview/png/10914877.png)
چکیده انگلیسی
To determine whether the EP4 receptor for prostaglandin E2 (PGE2) contributes to the tumor promoting activity of PGs in murine skin, EP4 over-expressing mice (BK5.EP4) were generated and subjected carcinogenesis protocols. An initiation/promotion protocol resulted in 25-fold more squamous cell carcinomas (SCCs) in the BK5.EP4 mice than wild type (WT) mice. An increase in SCCs also occurred following treatment with initiator alone or UV irradiation. The initiator dimethylbenz[a]anthracene caused cytotoxicity in BK5.EP4, but not WT mice, characterized by sloughing of the interfollicular epidermis, regeneration and subsequent SCC development. A comparison of transcriptomes between BK5.EP4 and WT mice treated with PGE2 showed a significant upregulation of a number of genes known to be associated with tumor development, supporting a pro-tumorigenic role for the EP4 receptor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Oncology - Volume 8, Issue 8, December 2014, Pages 1626-1639
Journal: Molecular Oncology - Volume 8, Issue 8, December 2014, Pages 1626-1639
نویسندگان
Melissa S. Simper, Joyce E. Rundhaug, Carol Mikulec, Rebecca Bowen, Jianjun Shen, Yue Lu, Kevin Lin, Inok Surh, Susan M. Fischer,