TRPP2 modulates ryanodine- and inositol-1,4,5-trisphosphate receptors-dependent Ca2+ signals in opposite ways in cerebral arteries

- TRPP2 channel involves in calcium signaling.
- TRPP2 modulates release of intracellular calcium store due to both ryanodine- and inositol-1,4,5,-trisphosphate receptors in opposite ways.
- The level of expression of TRPP2 modulates also vascular reactivity.
- Aging decreases the efficiency of the TRPP2-induced regulation of Ca2+ signals depending of intracellular stores.