کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10929273 1093235 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Participation of lectin chaperones and thiol oxidoreductases in protein folding within the endoplasmic reticulum
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Participation of lectin chaperones and thiol oxidoreductases in protein folding within the endoplasmic reticulum
چکیده انگلیسی
Protein folding within the endoplasmic reticulum occurs in conjunction with a complex array of molecular chaperones and folding catalysts that assist the folding process as well as function in quality control processes to monitor the outcome. In this review, we summarize recent advances in the calnexin/calreticulin chaperone system that is directed primarily toward Asn-linked glycoproteins, as well as the protein disulfide isomerase family of enzymes that catalyze disulfide formation, reduction, and isomerization. We highlight issues related to function and substrate specificity as well as the functional interplay between the two systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Cell Biology - Volume 23, Issue 2, April 2011, Pages 157-166
نویسندگان
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