کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10956195 | 1098785 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Wnt/β-catenin signaling regulates follicular development by modulating the expression of Foxo3a signaling components
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کلمات کلیدی
WntIWRCytochrome P450 aromataseIWR-1p53-upregulated modulator of apoptosisCYP19A1CYP11A13β-Hydroxysteroid dehydrogenaseWnt3afrizzledFZDCTNNB1terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelingFBSGSK3βLiClFOXO3aLRP3β-HSDAPCDMSO - DMSOTCF/LEF - TCF / LEFadenomatosis polyposis coli - آدنوماتوز پولیپوز کولیβ-catenin - بتا-کاتنینTUNEL - تونلforkhead Box O - جعبه O جعبه ODimethylsulfoxide - دیمتیل سولفواکسیدStar - ستارهfetal bovine serum - سرم جنین گاوWnt/β-catenin signaling - سیگنال Wnt / β-cateninFoxO - فاکسوfollicle culture - فرهنگ فولیکولSteroidogenic acute regulatory protein - پروتئین حاکم استروئیدوژنیک حادPUMA - پوماGlycogen synthase kinase 3β - گلیکوزین سنتاز کیناز 3β
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
Wnt signaling is an evolutionarily conserved pathway that regulates cell proliferation, differentiation and apoptosis. To investigate the possible role of Wnt signaling in the regulation of ovarian follicular development, secondary follicles were isolated and cultured in vitro in the presence or absence of its activator (LiCl or Wnt3a) or inhibitor (IWR-1). We have demonstrated that activation of β-catenin signals by activators dramatically suppressed follicular development by increasing granulosa cell apoptosis and inhibiting follicle steroidogenesis. In contrast, inhibition of Wnt signaling by IWR-1 was observed with better developed follicles and increased steroidogenesis. Further studies have shown that the transcription factor Forkhead box O3a (Foxo3a) and its downstream target molecules were modulated by the activators or the inhibitor. These findings provide evidence that Wnt signaling might negatively regulate follicular development potentially through Foxo3a signaling components.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 382, Issue 2, 15 February 2014, Pages 915-925
Journal: Molecular and Cellular Endocrinology - Volume 382, Issue 2, 15 February 2014, Pages 915-925
نویسندگان
Lei Li, Shao-Yang Ji, Jun-Ling Yang, Xi-Xia Li, Jun Zhang, Yang Zhang, Zhao-Yuan Hu, Yi-Xun Liu,