کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10961246 | 1101540 | 2015 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Flupirtine: Preliminary Pharmacokinetics in the Donkey
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
Flupirtine (FLU) is a nonopioid analgesic drug with no antipyretic or antiphlogistic effects labeled for humans. It does not induce the side effects associated with the classical drugs used as pain relievers (Non steroidal antiinflammatory drugs and opioids) in human beings. The aim of this study was to evaluate the pharmacokinetic profiles of FLU after IV and PO administrations in healthy donkeys. Six Amiata breed adult jennies were randomly assigned to two treatment groups using an open, 2 Ã 2 Latin-square crossover study design. Group 1 (n = 3) received a single dose of 1Â mg/kg of FLU injected IV into the jugular vein. Group 2 (n = 3) received FLU (5Â mg/kg) via nasogastric tube. The washout period was 1 week. Blood samples (5Â mL) were collected at 0.083, 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 10, 24, 36, and 48Â hours, and plasma was then analyzed by a validated high-performance liquid chromatography method. No adverse effects were noticed in either administration group. After IV and PO administrations, FLU was detectable in plasma for up to 24Â hours. The mean elimination half-life was longer after PO (10.81Â hours) than after IV (0.90Â hours) administration. The clearance was fast, and the area under the plasma concentration-time curve was small, findings consistent with a low PO bioavailability of about 20%. The pharmacokinetic trend of FLU in donkeys was different from those earlier reported in cats and dogs. Further studies are needed to understand if this active ingredient may be used in donkeys.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Equine Veterinary Science - Volume 35, Issue 4, April 2015, Pages 309-314
Journal: Journal of Equine Veterinary Science - Volume 35, Issue 4, April 2015, Pages 309-314
نویسندگان
Mario Giorgi, Fulvio Laus, Virginia De Vito, Helen Owen, Amnart Poapolathep, Emanuele Paggi, Cecilia Vullo,