کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11010646 | 1807145 | 2018 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Subchronic toxicity evaluation of 5-hexenyl isothiocyanate, a nature identical flavoring substance from Wasabia japonica, in F344/DuCrj rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
5-Hexenyl isothiocyanate (5-HeITC) is a naturally derived flavoring substance from Wasabia japonica. To clarify the toxicological profile of 5-HeITC, we performed a subchronic toxicity study of 5-HeITC with intragastric administration at daily doses of 0, 3, 12, or 48â¯mg/kg body weight (BW) to 6-week-old male and female F344/DuCrj rats for 13 weeks. Body weight gain was decreased in the male 48â¯mg/kg BW group. Decreased triglycerides were observed in the male over 12â¯mg/kg BW and female 48â¯mg/kg BW groups. Decreased total cholesterol was observed in the male 48â¯mg/kg BW group. Increases in relative liver weights were observed in the male 48â¯mg/kg BW and female over 12â¯mg/kg BW groups. Increases in absolute and relative heart weights were observed in the female over 12â¯mg/kg BW groups. Simple hyperplasia in the urinary bladder was found in the male and female 12â¯mg/kg BW groups, and nodular hyperplasia was found in the female 48â¯mg/kg BW group. Based on these findings, the target organs of 5-HeITC were determined to be the urinary bladder, heart, and liver. The no-observed-adverse-effect level of 5-HeITC for both sexes was estimated to be 3â¯mg/kg BW.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 122, December 2018, Pages 80-86
Journal: Food and Chemical Toxicology - Volume 122, December 2018, Pages 80-86
نویسندگان
Jun-ichi Akagi, Young-Man Cho, Yasuko Mizuta, Takeshi Toyoda, Kumiko Ogawa,