کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2584824 1561747 2016 13 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
A 90-day oral (dietary) toxicity and mass balance study of corn starch fiber in Sprague Dawley rats
ترجمه فارسی عنوان
سمیت 90 روز خوراکی (غذایی) و مطالعه موازنه جرم از فیبر نشاسته ذرت در موش نژاد Sprague Dawley
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موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


• Subchronic dietary administration of up to 10,000 mg corn starch fiber/kg-bw/day to rats resulted in no adverse effects.
• The toxicity profile of corn starch fiber was comparable to polydextrose at an equivalent dose level.
• After [14C]-corn starch fiber dosing, nearly complete excretion of the administered dose occurred over 168 h post-dosing.

The potential toxicity of corn starch fiber was assessed and compared to polydextrose, a commonly used bulking agent with a long history of safe use in the food supply. Groups of male and female Crl:CD(SD) rats were fed 0 (control), 1,000, 3,000, or 10,000 mg/kg-bw/day corn starch fiber in the diet for 90 days. The polydextrose reference article was offered on a comparable regimen at 10,000 mg/kg-bw/day. Following a single gavage dose of [14C]-corn starch fiber on study day 13 or 90, the mass balance of the test article was assessed by analysis of excreta samples collected from 0 to 168 h post-dose. There were no toxicologically or biologically relevant findings in any of the test article-treated groups. The few minor differences observed between the corn starch fiber and polydextrose exposed groups were considered to be due to normal biological variation. Following [14C]-corn starch fiber dosing, nearly complete excretion of the administered dose occurred over 168 h post-dosing, with the majority excreted in the feces. The dietary no-observed-adverse-effect level of corn starch fiber after 90 days was 10,000 mg/kg-bw/day. Similar toxicity profiles for corn starch fiber and polydextrose were observed due to the structural and compositional similarities of these materials.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 97, November 2016, Pages 57–69
نویسندگان
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