کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1101413 953567 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Factors Influencing Botulinum Toxin Dose Instability in Spasmodic Dysphonia Patients
ترجمه فارسی عنوان
عوامل مؤثر بر بی ثباتی دوز بوتولینوم توکسین در بیماران دیسفونی اسپاستمی
کلمات کلیدی
دیسفونی اسپاستمی سم بوتولینوم، مصرف دارو اختلال اسپاستیک، اسپاسم حنجره، بوتاکس، عواقب
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
چکیده انگلیسی

SummaryObjectiveMany patients with spasmodic dysphonia (SD) see consistent effects from botulinum toxin (BTX) injections of the same dose, whereas others require dosage changes over time. We sought to determine whether demographics (age and gender) or environmental factors (smoking) affect the long-term stability of BTX dosing in these patients.Study DesignRetrospective review.MethodsCharts of all patients undergoing BTX injection for adductor SD were reviewed. Dosage change, defined as whether there was any difference in total dosage used between two beneficial injections, was used as a measure of dosing stability. Beneficial injections were indicated by a voice rating score of at least three of four and any non-zero duration of improved voice. Logistic regression analysis was performed to determine whether age, gender, smoking status, or duration of treatment correlated with odds of having a dosage change.ResultsA total of 211 patients were ultimately included. Age, gender, and smoking status were all found to have no correlative effect on dosing stability. The only factor that was predictive of dose stability was the number of previous beneficial injections, as every additional injection led to decreased odds of a change in dosage for the next injection (odds ratio = 0.964; 95% confidence interval = 0.947–0.981).ConclusionsDosage of BTX injections for long-term treatment of SD has a significant propensity to remain stable over time. Factors such as age, gender, and smoking status do not appear to influence the dosage stability. These findings should allow for better patient counseling regarding expectations for their long-term treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Voice - Volume 29, Issue 3, May 2015, Pages 352–355
نویسندگان
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