کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11015205 | 1788350 | 2019 | 39 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phyto-miRNAs-based regulation of metabolites biosynthesis in medicinal plants
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کلمات کلیدی
FpsTIAsshort interfering RNAsQPTHD-ZIPsncRNAsprecursor miRNAsMREPGMPSMSPHATRPEsiRNAsDArTmiRNAsAACTHMGRRNA interference - RNA تداخل کنندهRNAi - RNA سرکوبگر،RNA مداخلهگر، RNA خاموش کنندهnon-coding RNAs - RNA های غیر کدگذاریAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Terpenoid indole alkaloids - آلکالوئید ترپنوئید و اندولBenzylisoquinoline alkaloids - آلکالوئیدهای بنسیلیووینولینsqualene epoxidase - اسکوالن اپوکسیازPSO - بهینه سازی ازدحام ذراتmicroRNAs - ریز آرانایBias - سوگیری یا سوگراییfarnesyl diphosphate synthase - فارسیل دی فسفات سنتازphosphoglycerate mutase - فسفوگلیسرات موتازPlant secondary metabolites - متابولیت های ثانویه گیاهیMetabolic engineering - مهندسی متابولیکpre-miRNAs - پیش از miRNAsMedicinal plants - گیاهان دارویی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Medicinal plants, are known to produce a wide range of plant secondary metabolites (PSMs) applied as insecticides, drugs, dyes and toxins in agriculture, medicine, industry and bio-warfare plus bio-terrorism, respectively. However, production of PSMs is usually in small quantities, so we need to find novel ways to increase both quantity and quality of them. Fortunately, biotechnology suggests several options through which secondary metabolism in plants can be engineered in innovative ways to: 1) over-produce the useful metabolites, 2) down-produce the toxic metabolites, 3) produce the new metabolites. Among the ways, RNA interference (RNAi) technology which involves gene-specific regulation by small non-coding RNAs (sncRNAs) have been recently emerged as a promising tool for plant biotechnologist, not only to decipher the function of plant genes, but also for development of the plants with improved and novel traits through manipulation of both desirable and undesirable genes. Among sncRNAs, miRNAs have been recorded various regulatory roles in plants such as development, signal transduction, response to environmental stresses, metabolism. Certainly, the use of miRNAs in metabolic engineering requires identification of miRNAs involved in metabolites biosynthesis, understanding of the biosynthetic pathways, as well as the identification of key points of the pathways in which the miRNAs have their own effect. Thus, we firstly consider these three issues on metabolic engineering of medicinal plants. Our review shows, application of miRNAs can open a novel perspective to metabolic engineering of medicinal plants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 682, 15 January 2019, Pages 13-24
Journal: Gene - Volume 682, 15 January 2019, Pages 13-24
نویسندگان
M. Sabzehzari, M.R. Naghavi,