کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11025739 | 1666522 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The significant role of interleukin-6 and its signaling pathway in the immunopathogenesis and treatment of breast cancer
ترجمه فارسی عنوان
نقش مهم اینترلوکین -6 و مسیر سیگنالینگ آن در ایمونوپاتوژنز و درمان سرطان پستان
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کلمات کلیدی
اینترلوکین -6، گیرنده اینترلوکین -6، سرطان پستان، رفتار،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
چکیده انگلیسی
Despite remarkable improvements in cancer treatment approaches, breast cancer is still the main cause of cancer-related death in women. Its principal cause is the resistance of the cancer cells against conventional anticancer therapeutics, mainly in advanced disease stages. It has been shown that chronic inflammation in the tumor microenvironment facilitates tumor growth and induces resistance toward chemo- and radiotherapy. Overexpression of interleukin-6 (IL-6) cytokine in the tumor microenvironment has been demonstrated in numerous tumors including breast cancer. Tumor cells and tumor-associated fibroblasts are the major sources of IL-6 secretion in the tumor microenvironment. Several studies have demonstrated the immunopathogenic function of IL-6 and its signaling in the tumor growth, metastasis, and therapeutic resistance in the breast cancer. Therefore, it seems that targeting IL-6 and/or its receptor in combination with other potent anticancer therapies may be a potent therapeutic approach for breast cancer therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 108, December 2018, Pages 1415-1424
Journal: Biomedicine & Pharmacotherapy - Volume 108, December 2018, Pages 1415-1424
نویسندگان
Ali Masjedi, Vida Hashemi, Mohammad Hojjat-Farsangi, Ghasem Ghalamfarsa, Gholamreza Azizi, Mehdi Yousefi, Farhad Jadidi-Niaragh,