کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11028054 1666124 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A computer simulation of short-term adaptations of cardiovascular hemodynamics in microgravity
ترجمه فارسی عنوان
شبیه سازی کامپیوتری از سازگاری کوتاه مدت همودینامیک قلب و عروق در میکرو گرانشی
کلمات کلیدی
میکروگرامیت، همودینامیک قلب و عروق، شبیه سازی، جابجایی سیالات، فشار منفی بدن پایین،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
چکیده انگلیسی
Astronauts in the microgravity environment experience significant changes in their cardiovascular hemodynamics. In this study, a system-level numerical model has been utilized to simulate the short-term adaptations of hemodynamic parameters due to the gravitational removal in space. The effect of lower body negative pressure (LBNP) as a countermeasure has also been simulated. The numerical model was built upon a lumped-parameter Windkessel model by incorporating gravity-induced hydrostatic pressure and transcapillary fluid exchange modules. The short-term (in the time scale of seconds and minutes) adaptations of the cardiac functions, blood pressure, and fluid volumes have been analyzed and compared with physiological data. The simulation results suggest microgravity induces a decrease in aortic pressure, heart rate, lower body capillary pressure and volume, and an increase in stroke volume, upper body capillary pressure and volume. The activation of LBNP causes an immediate increase in lower body blood volume and a gradual decrease in upper body blood volume. As a result, the fluid shift due to microgravity could be reversed by the LBNP application. LBNP also counters the impacts of microgravity on the cardiac functions, including heart rate and stroke volume. The simulation results have been validated using available physiological data obtained from spaceflight and parabolic flight experiments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers in Biology and Medicine - Volume 102, 1 November 2018, Pages 86-94
نویسندگان
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