Hybrid inorganic (nonporous silica)/organic (alginate) core-shell platform for targeting a cisplatin-based Pt(IV) anticancer prodrug

Amino-decorated nonporous silica nanoparticles were further coated with alginic acid to produce a potential biocompatible delivery system for Pt(IV) antitumor prodrug (OC‑6‑44)‑acetato(β‑alaninato)diamminedichloridoplatinum(IV), through the formation of amide bonds. The conjugate was more active than both cisplatin and the Pt(IV) precursor, due to its more efficient cell uptake.112