Recent Progress of DNAzyme-Nanomaterial Based Biosensors

DNAzymes, screened through in vitro selection, were artificial nucleic acids with catalytic function. They could cleave specific substrates in the presence of cofactors with unique characteristics, such as high catalytic activity, high specificity for cofactors, excellent stability, and easy to synthesize and modify. The combination of DNAzymes with nanomaterials could retain the DNAzyme activity and realize the functional integration of recognition and signal transduction, promoting rapid development of biosensors. In the current paper, we have mainly reviewed the recent progress of DNAzyme-nanomaterial based biosensors, and the nanomaterials included gold nanoparticles, graphene, quantum dots, magnetic nanomaterials, and so on.

This paper reviewed the recent progress of DNAzyme-nanomaterial-based biosensors, and the nanomaterials included gold nanoparticles, graphene, quantum dots, magnetic nanomaterials etc. The combination of DNAzymes with nanomaterials could retain the DNAzyme activity and realize the functional integration of recognition and signal transduction, promoting rapid development of biosensors.Figure optionsDownload as PowerPoint slide