Characterization of Synthesized Titanium Oxide Nanoclusters by MALDI-TOF Mass Spectrometry

Titania represents an important material that has wide applications. The bactericidal efficiency of TiO2 has been shown to be dependent on the size of the nanoparticles, so it is important to be able to reliably estimate their dimensions. In this study, a stable TiO2 cluster suspension is produced by the thermal solvent process, and ultrasmall clusters (<1 nm) with different sizes are obtained by size-selection treatment. MALDI-TOF-MS and LDI-TOF-MS are shown to be useful for characterization of these ultrasmall nanoparticles. Peak maxima are found to correlate with nanoparticle size, and the possibility of using these mass spectrometry–based approaches to estimate nanoparticle size is affirmed. The size distributions of TiO2 nanoparticles obtained from MALDI- and LDI-TOF-MS are in good agreement with parallel TEM observations. Finally, PSD analysis of inorganic nanomaterials is performed and valuable information about the structure of analytes has been obtained.