Molecularly imprinted nanoparticles with nontailing peaks in capillary electrochromatography

► Molecularly imprinted nanoparticles with size of 50-80 nm were prepared with zopiclone as template. ► Baseline separation of enantiomer separation can be achieved with imprinted nanoparticles in CEC mode. ► Polymerization factors on the imprinting effect of MIP nanoparticles were investigated. ► Imprinted nanoparticles showed higher efficiency for template with good peak symmetry.