Hyperbranched polyglycerol/graphene oxide nanocomposite reinforced hollow fiber solid/liquid phase microextraction for measurement of ibuprofen and naproxen in hair and waste water samples

• The novel technique Hollow Fiber solid-liquid phase microextraction (HF-SLPME) was applied in this research.
• Sorbent capability of hyperbranched polyglycerol/graphene oxide nanocomposite is demonstrated.
• Non-steroidal anti-inflammatory drugs have been selected as target compound.
• It has been applied to the analysis of human samples; hair, and wastewater.
• The limit of detections are 2.95 and 1.51 ng mL−1 for ibuprofen and naproxen respectively.

A new design of hyperbranched polyglycerol/graphene oxide nanocomposite reinforced hollow fiber solid/liquid phase microextraction (HBP/GO −HF-SLPME) coupled with high performance liquid chromatography used for extraction and determination of ibuprofen and naproxen in hair and waste water samples. The graphene oxide first synthesized from graphite powders by using modified Hummers approach. The surface of graphene oxide was modified using hyperbranched polyglycerol, through direct polycondensation with thionyl chloride. The ready nanocomposite later wetted by a few microliter of an organic solvent (1-octanol), and then applied to extract the target analytes in direct immersion sampling mode.After the extraction process, the analytes were desorbed with methanol, and then detected via high performance liquid chromatography (HPLC). The experimental setup is very simple and highly affordable. The main factors influencing extraction such as; feed pH, extraction time, aqueous feed volume, agitation speed, the amount of functionalized graphene oxide and the desorption conditions have been examined in detail. Under the optimized experimental conditions, linearity was observed in the range of 5–30,000 ng mL−1 for ibuprofen and 2–10,000 ng mL−1 for naproxen with correlation coefficients of 0.9968 and 0.9925, respectively. The limits of detection were 2.95 ng mL−1 for ibuprofen and 1.51 ng mL−1 for naproxen. The relative standard deviations (RSDs) were found to be less than 5% (n = 5).