کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1219741 1494552 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cancer chemopreventive theasaponin derivatives from the total tea seed saponin of Camellia sinensis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Cancer chemopreventive theasaponin derivatives from the total tea seed saponin of Camellia sinensis
چکیده انگلیسی


• Natural QR inducing agents were screened and identified from the hydrolysis products of the total tea seed saponin in Camellia sinensis.
• Compounds 7, 12 and 14 were selected as potential QR inducing agents with IR value at 2.87, 3.02 and 2.33.

Natural QR (quinine oxidoreductase) inducers play critical roles in cancer chemoprevention. Because tea seed saponins of Camellia sinensis exhibited significant QR inducing activities, this study aimed to find bioactive theasaponin derivatives by structure modification on the sugar part and acyl groups. Three kinds of hydrolysis methods were employed to afford 7 major acid hydrolysis products (1–7), 10 alkaline hydrolysates (8–17) and 2 derivatives (3, 18) by oxidative alkaline-degradation. They were elucidated as kaempferol (1), camelliagenin B (2), camelliagenin A (3), 21-O-angeloybarringtogenol C (4), 5-hydroxymethylfurfural (5), 16-O-angeloybarringtogenol (6), 23-aldehyde-16-O-angeloybarringtogenol (7), desacyl-assamsaponin D (8), desacyl-theasaponin A5 (9), desacyl-assamsaponin E (10), desacyl-theasaponin C1 (11), desacyl-theasaponin E (12), desacyl-theasaponin E13 (13), desacyl-assamsaponin F (14), desacyl-theasaponin F1 (15), desacyl-theasaponin G (16), desacyl-assamsaponin A (17), camelliagenin C (18) accordingly. By the QR inducing activity assay, compounds 7, 12 and 14 were selected as potential QR inducing agents with IR value at 2.87, 3.02 and 2.33.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 12, January 2015, Pages 192–198
نویسندگان
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