کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1226391 1494825 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Iron and copper in progressive demyelination – New lessons from Skogholt's disease
ترجمه فارسی عنوان
آهن و مس در دمیلینه شدن مترقی - درس های جدید از بیماری Skogholt
کلمات کلیدی
فلز مس؛ دمیلینه شدن؛ اهن؛ ام اس ؛ بیماری Skogholt
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی

The pathophysiological mechanisms of progressive demyelinating disorders including multiple sclerosis are incompletely understood. Increasing evidence indicates a role for trace metals in the progression of several neurodegenerative disorders. The study of Skogholt disease, a recently discovered demyelinating disease affecting both the central and peripheral nervous system, might shed some light on the mechanisms underlying demyelination. Cerebrospinal fluid iron and copper concentrations are about four times higher in Skogholt patients than in controls. The transit into cerebrospinal fluid of these elements from blood probably occurs in protein bound form. We hypothesize that exchangeable fractions of iron and copper are further transferred from cerebrospinal fluid into myelin, thereby contributing to the pathogenesis of demyelination. Free or weakly bound iron and copper ions may exert their toxic action on myelin by catalyzing production of oxygen radicals. Similarities to demyelinating processes in multiple sclerosis and other myelinopathies are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Trace Elements in Medicine and Biology - Volume 31, July 2015, Pages 183–187
نویسندگان
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